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Test Category: Immunology

Investigation Name:Cardiolipin antibody (IgM)

Alias or Abbreviation:Cardiolipin, Phospholipid

Intro:

Indication: Antiphospholipid syndrome (APS) and to evaluate the thrombotic risk in patients with systemic lupus erythematosus (SLE). Further information: NOTE: Tests available for both IgG and IgM assays and should be requested separately. The international consensus statement states that anti-phospholipid syndrome can be diagnosed with: vascular thrombosis (blood clots) in any organ or tissue or pregnancy event (one or more miscarriages after 10th week of gestation, three or more miscarriages before 10th week of gestation, or one or more premature births before 34th week of gestation due to eclampsia) and persistently positive IgG or IgM anti-phospholipid antibodies at moderate-high titre (>40 GPL or MPL U/mL), or moderate-to-high titre beta-2 glycoprotein antibodies. Anti-cardiolipin antibodies should be positive on at two occasions at least 12 weeks apart.

Requestable Seperately?Yes

Minimum Sample Volume:1mL

Test Code:ACM

Sample Type:

Serum Gel Tube (Gold top)/ Plasma

Complex Reference Range:<10 MPL-U/mL = Negative

Collection Conditions / Other Information:1st class post or Transport

Referred to Another Laboratory?No

Storage Requirements:Ambient temperature

NPEX / PDF Reporting Available:Yes

EQA Scheme:Yes

Lead Contact Details:rwh-tr.bcpsimmunologyclinicalqueries@nhs.net

Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net

Methodology:Fluoroenzymeimmunoassay

UKAS Reference Number:9580 (recommended)

Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton

Minimum Request Interval (MRI):70 days (10 weeks) over 16y only