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Test Category: Immunology

Investigation Name:Tetanus Toxoid IgG antibody

Alias or Abbreviation:TET, FAB, Functional antibodies

Intro:

Indication: Immunodeficiency
Further information:
Functional antibodies should only be requested if there is a clinical suspicion of antibody deficiency (primary or secondary). The recommended first line Immunology tests are:-
• Immunoglobulin levels (IgG, IgA and IgM)
• Electrophoresis
The second line testing, which includes functional antibodies, should only be requested if:-
• There is a strong clinical history of recurrent or persistent infection
• At least 2 Immunoglobulin isotypes are lower than reference limits
• To assess immune response to vaccines (pre- and post-vaccine)

Pathology Laboratory:Immunology Laboratory

Requestable Seperately?Yes

Minimum Sample Volume:0.5mL

Test Code:TETA

Sample Type:

Serum Gel Tube (Gold top)

Complex Reference Range:<0.01 IU/mL= Susceptible
individual
0.01 – 0.15 IU/mL= Basic
level of full protection
>0.15 IU/mL= Full protected level

Collection Conditions / Other Information:1st class post or Transport

Referred to Another Laboratory?No

Storage Requirements:Ambient temperature

NPEX / PDF Reporting Available:Yes

EQA Scheme:Yes

Further information:Functional antibodies should only be requested if there is a clinical suspicion of antibody deficiency (primary or secondary) and as a second line test.

Lead Contact Details:rwh-tr.bcpsimmunologyclinicalqueries@nhs.net

Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net

Methodology:ELISA

UKAS Reference Number:9580

Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton