Test Category: Immunology
Investigation Name:C1 Esterase Inhibitor (functional)
Alias or Abbreviation:C1INH, Functional complement
Intro:
Indication:Hereditary Angioedema
Further information:
Most cases have reduced serum C1Inh levels. In 10% of cases there are normal or elevated levels of C1Inh but this is functionally inactive. In hereditary angioedema C4 levels are almost always reduced and C1q levels are normal.
In acquired angioedema (associated with B cell neoplasia) C1Inh is reduced and both C4 and C1q are also usually reduced.
Pathology Laboratory:Immunology Laboratory
Requestable Seperately?Yes
Part of Profile:No
Minimum Sample Volume:0.5mL
Expected Turnaround Time:21 Working days
Test Code:C1FA
Sample Type:
Sodium Citrate (blue top)Complex Reference Range:Normal = 70 –130%
Collection Conditions / Other Information:Sodium Citrated (Blue top) sample must be separated within 1 hour of collection and aliquots frozen below -80oC
Reference Laboratory Details:Immunology Dept, Medical School, Birmingham
Referred to Another Laboratory?Yes
Storage Requirements:Aliquot Plasma and Freeze at -80oC after separation within 1 hour after venepuncture.
Posting Address / Requirements:Sample to be referred to BCPS HUB within 1 hour of collection at ambient temperature. If sample has been separated and frozen, refer to HUB on ice to prevent thawing.
Further information:Laboratory use only: Plasma should be separated within the hour, frozen and sent to the referral laboratory to arrive frozen.
Lead Contact Details:rwh-tr.bcpsimmunologyclinicalqueries@nhs.net
Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net
Contact Number:01902 695 279 or Ext 85279
