Test Category: Immunology
Investigation Name:Cardiolipin antibody (IgM)

Alias or Abbreviation:Cardiolipin, Phospholipid
Intro:
Indication:Antiphospholipid syndrome (APS) and to evaluate the thrombotic risk in patients with systemic lupus erythematosus (SLE).
Further information:
NOTE: Tests available for both IgG and IgM assays and should be requested separately.
The international consensus statement states that anti-phospholipid syndrome can be diagnosed with: vascular thrombosis (blood clots) in any organ or tissue or pregnancy event (one or more miscarriages after 10th week of gestation, three or more miscarriages before 10th week of gestation, or one or more premature births before 34th week of gestation due to eclampsia) and persistently positive IgG or IgM anti-phospholipid antibodies at moderate-high titre (>40 GPL or MPL U/mL), or moderate-to-high titre beta-2 glycoprotein antibodies. Anti-cardiolipin antibodies should be positive on at two occasions at least 12 weeks apart.
Pathology Laboratory:Immunology laboratory
Requestable Seperately?Yes
Minimum Sample Volume:1mL
Expected Turnaround Time:21 working days
Test Code:ACM
Sample Type:
Serum Gel Tube (Gold top)/ PlasmaComplex Reference Range:<10 MPL-U/mL = Negative
Collection Conditions / Other Information:1st class post or Transport
Referred to Another Laboratory?No
Storage Requirements:Ambient temperature
NPEX / PDF Reporting Available:Yes
EQA Scheme:Yes
Lead Contact Details:rwh-tr.bcpsimmunologyclinicalqueries@nhs.net
Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net
Methodology:Fluoroenzymeimmunoassay
UKAS Reference Number:9580 (recommended)
Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton
Minimum Request Interval (MRI):70 days (10 weeks) over 16y only
Contact Number:01902 695279 or Ext 85279