Test Category: Immunology
Investigation Name:Centromere antibodies
Alias or Abbreviation:Centromere
Intro:
Indication:Investigation of unexplained Raynaud’s; suspected limited cutaneous systemic sclerosis/scleroderma (LcSSc); CREST syndrome.
Further information:
See Anti-nuclear antibody (ANA)
Anti-centromere antibodies are characteristic of the CREST syndrome (Calcinosis, Raynaud’s, Oesophageal dysmotility, Sclerodactyly and Telangiectasia), Limited cutaneous Systemic Sclerosis (LcSSc). They can also be present in a minority of cases of primary biliary cholangitis (PBC) and Sjögren’s syndrome where an SSc overlap syndrome may be present.
Pathology Laboratory:Immunology laboratory
Requestable Seperately?No
Minimum Sample Volume:1mL
Expected Turnaround Time:Frequency of testing: When requested Target: 1 day
Test Code:ANA
Sample Type:
Serum Gel Tube (Gold top)Complex Reference Range:Positive/ Negative
Collection Conditions / Other Information:1st class post or Transport
Referred to Another Laboratory?No
Storage Requirements:Ambient temperature
NPEX / PDF Reporting Available:Yes
EQA Scheme:Yes
Further information:Please note this forms part of the ANA test
Lead Contact Details:rwh-tr.bcpsimmunologyclinicalqueries@nhs.net
Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net
Methodology:Indirect Immunofluorescence
UKAS Reference Number:Awaiting assessment
Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton
Minimum Request Interval (MRI):180 days (6 months) over 16y only
Contact Number:01902 695279 or Ext 85279
