Test Category: Immunology
Investigation Name:Complement Classical Pathway CH50
Alias or Abbreviation:CH50, Functional complement
Intro:
Indication:Suspected Complement pathway defects, recurrent meningitis especially with encapsulated bacteria, familial SLE.
Further information:
CH50 results should always be interpreted in conjunction with Complement levels.
Decreased CH50 values may be caused by consumption or a deficiency of one or more of the classical complement components. Complete defects of particular classical pathway components, such as C1/2/3/4/5-C8, usually result in a CH50 value of zero.
CH50 provides an initial screening tool for investigation of complement deficiency in individuals with symptoms such as recurrent sinopulmonary bacterial infections. Autoimmune complex disease, such as SLE, can result in classical complement pathway consumption or be associated to a primary complement deficiency.
Pathology Laboratory:Immunology Laboratory
Requestable Seperately?Yes
Minimum Sample Volume:5mL
Expected Turnaround Time:28 working days
Test Code:CH50
Sample Type:
Serum Gel Tube (Gold top)Complex Reference Range:Normal range = 42 -95 U/mL
Low = 30 - 42 U/mL
Absent = <30 U/mL
Collection Conditions / Other Information:Urgent transport - Must be received in the laboratory within 1 hour of collection
Reference Laboratory Details:Immunology, Heartlands Hospital
Referred to Another Laboratory?Yes
Storage Requirements:Sample must be separated and aliquoted and stored below -20oC within 1 hour of collection
Posting Address / Requirements:Sample to be referred to BCPS HUB within 1 hour of collection at ambient temperature. If sample has been separated and frozen, refer to HUB on ice to prevent thawing.
NPEX / PDF Reporting Available:Yes
Further information:Laboratory use only: Sample to be referred to BCPS HUB within 1 hour of collection at ambient temperature. If sample has been separated and frozen, refer to HUB on ice to prevent thawing.
Lead Contact Details:rwh-tr.bcpsimmunologyclinicalqueries@nhs.net
Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net
UKAS Reference Number:8910
Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton
Minimum Request Interval (MRI):180 days (6 months) over 16y only
Contact Number:01902 695279 or Ext 85279
