Test Category: Immunology
Investigation Name:Gastric Parietal Cell antibody (GPC)
Alias or Abbreviation:GPC
Intro:
Indication:Autoimmune gastritis with or without pernicious anaemia.
Further information:
Forms part of the Liver Auto-immune profile which includes tests for:
• Mitochondrial antibody (AMA)
• Smooth muscle antibody (SMA)
• Liver- kidney microsomal antibody (LKM)
• Gastric Parietal antibody (GPC)
Gastric parietal cell antibodies (GPC) are directed against a parietal cell enzyme, the H+K+ATPase. The autoantibody is found at high frequency in association with autoimmune gastritis and a proportion of these patients will progress to develop pernicious anaemia. Gastric parietal cell antibodies are present in over 90% of patients with pernicious anaemia (Highly sensitive, but not specific).
Note: Where GPC antibodies are observed within the Liver autoimmune profile, an Intrinsic factor antibody will be automatically added on.
Pathology Laboratory:Immunology laboratory
Requestable Seperately?No
Minimum Sample Volume:1mL
Expected Turnaround Time:Frequency of testing: Daily Target: 5 days
Test Code:LKS
Sample Type:
Serum Gel Tube (Gold top)Complex Reference Range:Positive/ Negative
Collection Conditions / Other Information:1st class post or Transport
Referred to Another Laboratory?No
Storage Requirements:Ambient temperature
NPEX / PDF Reporting Available:Yes
EQA Scheme:Yes
Further information:Available as part of the Liver Auto-immune profile only (LKS)
Lead Contact Details:rwh-tr.bcpsimmunologyclinicalqueries@nhs.net
Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net
Methodology:Indirect Immunofluorescence
UKAS Reference Number:Awaiting assessment
Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton
Minimum Request Interval (MRI):180 days (6 months) over 16y only
Contact Number:01902 695 279 or Ext 85279
