Test Category: Immunology
Investigation Name:Liver-Kidney Microsomal antibodies (LKM) [Liver antibodies]
Alias or Abbreviation:LKM, Liver antibody
Accreditation:Yes
Intro:
Indication:Autoimmune Hepatitis (AIH)
Further information:
Anti LKM antibodies are associated with type two autoimmune hepatitis (AIH) and in some patients they are associated with hepatitis C infection. LKM antibodies are found only in a small number of patients with autoimmune chronic active hepatitis and drug-induced hepatitis, but are highly specific.
Forms part of the Liver Auto-immune profile which includes tests for:
• Mitochondrial antibody (AMA)
• Smooth muscle antibody (SMA)
• Liver- kidney microsomal antibody (LKM)
• Gastric Parietal antibody (GPC)
Pathology Laboratory:Immunology laboratory
Requestable Seperately?No
Part of Profile:Autoimmune Liver Disease Screen
Tests in Profile:AMA, SMA, LKM, GPC
Minimum Sample Volume:1mL
Expected Turnaround Time:5 days
Test Code:BAS
Sample Type:
Serum Gel Tube (Gold top)Complex Reference Range:Positive/ Negative
Referred to Another Laboratory?No
Storage Requirements:Refrigerate (2 – 8C) after serum separation
Posting Address / Requirements:Ambient temperature, First Class Post
NPEX / PDF Reporting Available:Yes
EQA Scheme:Yes
Further information:Available as part of the Liver Auto-immune profile only (LKS)
Lead Contact Details:rwh-tr.bcpsimmunologyclinicalqueries@nhs.net
Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net
Methodology:Indirect Immunofluorescence
UKAS Reference Number:9580 (recommended)
Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton
Minimum Request Interval (MRI):180 days (6 months) over 16y only
Contact Number:01902 695 279 or Ext 85279
