Test Category: Immunology
Investigation Name:Pneumococcal Serotype Specific Antibodies
Intro:
Indication:Immunodeficiency
Further information:
Functional antibodies should only be requested if there is a clinical suspicion of antibody deficiency (primary or secondary).
The recommended first line Immunology tests are:-
• Immunoglobulin levels (IgG, IgA and IgM)
• Electrophoresis
The second line testing, which includes functional antibodies, should only be requested if:-
• There is a strong clinical history of recurrent or persistent infection
• At least 2 Immunoglobulin isotypes are lower than reference limits
• To assess immune response to vaccines (pre- and post-vaccine)
This assay is used to monitor IgG responses to the Prevenar and Pneumovax vaccines, in patients with suspected immunodeficiency. Samples should ideally be tested pre- and post- vaccination. The serotypes available are 1, 3, 4, 5, 6b, 7F, 9V, 14, 18c, 19A, 19F and 23F which are in both the Pneumovax and Prevenar vaccines.
Pathology Laboratory:Immunology Laboratory
Requestable Seperately?Yes
Minimum Sample Volume:1mL
Expected Turnaround Time:5 weeks
Test Code:PNSS
Sample Type:
Serum Gel Tube (Gold top)Complex Reference Range:See report
Collection Conditions / Other Information:Functional antibodies should only be requested if there is a clinical suspicion of antibody deficiency (primary or secondary).
The recommended first line Immunology tests are:-
• Immunoglobulin levels (IgG, IgA and IgM)
• Electrophoresis
Reference Laboratory Details:Immunology and Protein Reference unit, Sheffield
Referred to Another Laboratory?Yes
Storage Requirements:Ambient temperature, First Class Post
Posting Address / Requirements:Refrigerate (2 – 8C) after serum separation
Lead Contact Details:rwh-tr.bcpsimmunologyclinicalqueries@nhs.net
Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net
UKAS Reference Number:Not on 8494 scope
Contact Number:01902 695 279 or Ext 85279
