Test Category: Specialist Biochemistry
Investigation Name:Adalimumab Therapeutic Drug Monitoring
Alias or Abbreviation:Humira
Accreditation:UKAS ISO15189:2022 Accredited test: On scope
Intro:
Adalimumab (Humira®) is a humanised monoclonal antibody directed against tumour necrosis factor-alpha (TNF-α), approved for use in the treatment of various chronic inflammatory diseases including rheumatoid arthritis, severe Crohn’s disease and ankylosing spondylitis.Therapeutic drug monitoring of Adalimumab allows optimisation of treatment by ensuring serum trough drug levels are within the therapeutic range and also identifies patients who have developed a loss of response, potentially through development of anti-drug antibodies.
Requestable Seperately?Yes
Minimum Sample Volume:1ml serum. Minimum serum volume required: 200µl
Expected Turnaround Time:7 working days
Test Code:ADAP
Sample Type:
Serum Gel Tube (Gold top) 1ml serum.Complex Reference Range:Adalimumab level >5 μg/mL is regarded as therapeutic.
Adalimumab level ≤5 μg/mL is regarded as sub-therapeutic.
Collection Conditions / Other Information:Adalimumab levels should be measured as a trough sample (i.e. just before the next infusion is given).
The therapeutic cut-off used only applies to patients on maintenance Adalimumab therapy.
Referred to Another Laboratory?No
Storage Requirements:Store at 2-8 0ᵒC prior to postage.
Posting Address / Requirements:Ambient Temperature, 1st Class Post,
Sandwell Health Campus
Specialist Chemistry
Pathology Department
Lyndon,
B71 4HJ
NPEX / PDF Reporting Available:Yes
EQA Scheme:Currently no EQA scheme is available. We participate in a quarterly sample share scheme alongside The Royal Devon & Exeter NHS Trust and Protein Reference Unit, Sheffield.
Lead Contact Details:Consultant Clinical Scientist, Hayley Sharrod-Cole,
Email: hayley.sharrod.cole@nhs.net
Email Address For Chasing Results:rwh-tr.bcpsspecialistchemistryenquiries@nhs.net
Site Sample Tested:Manuals Laboratory- Sandwell Health Campus
Cost:Please email: bcpspathology.info@nhs.net for further details
Contact Number:0121 507 5162
