Test Category: Immunology
Investigation Name:Muscle Specific Tyrosine Kinase (MUSK)
Alias or Abbreviation:Musk
Intro:
Indication:Generalized Acetylcholine Receptor seronegative MG.
Further information:
Muscle specific tyrosine kinase (MUSK) is a surface membrane enzyme that is essential in aggregating Acetylcholine receptor during the development of the neuromuscular junction.
Recent studies have shown that antibodies to Musk are present in 40% to 50% of patients with generalized Acetylcholine Receptor seronegative MG. Anti-Musk antibodies have not been found in patients with purely ocular myasthenia or in those with anti-acetylcholine receptor antibodies.
Pathology Laboratory:Immunology Laboratory
Requestable Seperately?Yes
Minimum Sample Volume:1ml
Expected Turnaround Time:3 Weeks
Test Code:MUSK
Sample Type:
Serum Gel Tube (Gold top)Complex Reference Range:Positive/ Negative
Reference Laboratory Details:The Neuroscience laboratories, The Walton Centre, Liverpool
Referred to Another Laboratory?Yes
Storage Requirements:Ambient temperature
Posting Address / Requirements:1st class post/ Trust transport
Lead Contact Details:Clinical queries email:
rwh-tr.bcpsimmunologyclinicalqueries@nhs.net
Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net
Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton
Contact Number:01902 695 279 or Ext 85279
