Test Category: Immunology
Investigation Name:Aquaporin 4 (AQP4) Antibodies
Alias or Abbreviation:AQP4, NMO
Intro:
Indication:Neuromyelitis optica or Devic’s disease.
Further information:
Aquaporin 4 (AQP4) is the major autoantigen in neuromyelitis optica (NMO or Devic's disease). Antibodies to AQP4 are found in >80% of NMO patients and around 50% of patients with longitudinally extensive transverse myelitis. They are infrequent in patients with optic neuritis without spinal cord involvement.
Pathology Laboratory:Immunology Laboratory
Requestable Seperately?Yes
Minimum Sample Volume:1 mL
Expected Turnaround Time:21 working days
Test Code:AQUS
Sample Type:
Serum Gel Tube (Gold top)Complex Reference Range:Positive/ Negative
Collection Conditions / Other Information:Aquaporin 4 (AQP4) is the major autoantigen in neuromyelitis optica (NMO, or Devic's disease). Antibodies to AQP4 are found in >80% of NMO patients and around 50% of patients with longitudinally extensive transverse myelitis.
They are infrequent in patients with optic neuritis without spinal cord involvement. Patients with AQP4 antibodies are at risk of relapsing and immunosuppressive treatment is currently recommended.
Reference Laboratory Details:Immunology Department, Medical School, Birmingham
Referred to Another Laboratory?Yes
Storage Requirements:Ambient temperature
Posting Address / Requirements:1st class post/ Trust transport
Lead Contact Details:Contact for clinical querie: rwh-tr.bcpsimmunologyclinicalqueries@nhs.net
Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net
Site Sample Tested:New Cross Hub laboratory
Contact Number:01902 695 279 or Ext 85279
