Test Category: Immunology
Investigation Name:C1Q Level
Alias or Abbreviation:C1Q
Intro:
Indication:Differential diagnosis of acquired angioedema. Low levels can be seen in SLE, glomerulonephritis and recurrent infections.
Further information:
C1q is the initiating molecule for the classical activation pathway of complement. Deficiencies or defects in the molecule lead to a reduced or absent CH50 value.
Familial deficiency is rare but reduced levels may be associated with SLE, recurrent bacterial infections and with glomerulonephritis [1,2].
C1q levels are usually only measured in cases where CH50 is absent or the patient has increased susceptibility to infection. The exception to this is in the identification of the consumptive defect in acquired angioedema, where levels are almost always low.
Pathology Laboratory:Immunology Laboratory
Requestable Seperately?Yes
Minimum Sample Volume:2ml
Expected Turnaround Time:21 Working days
Test Code:C1Q
Sample Type:
Serum Gel Tube (Gold top)Complex Reference Range:Normal = 50 – 250 mg/L
Reference Laboratory Details:Immunology, Sheffield
Referred to Another Laboratory?Yes
Further information:Laboratory use only:
Must be received in the laboratory within 1 hour of collection for immediate freezing and sent to the referral laboratory to arrive frozen.
Lead Contact Details:Clinical queries email:
rwh-tr.bcpsimmunologyclinicalqueries@nhs.net
Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net
Contact Number:01902695279
