Test Category: Haematology
Investigation Name:Clauss Fibrinogen
Alias or Abbreviation:Clauss FGEN
Accreditation:UKAS ISO15189:2022 Accredited test: On scope
Intro:
The fibrinogen Clauss method is a quantitative assay using thrombin to measure fibrinogen levels in plasma. It is used to assess the functional concentration of fibrinogen, which plays a crucial role in the final stage of the coagulation cascade. This test is commonly used in the investigation of bleeding disorders, monitoring of liver disease, assessment of disseminated intravascular coagulation (DIC), and as part of routine preoperative screening.In this method, patient plasma is mixed with a high concentration of thrombin, which rapidly converts fibrinogen to fibrin. The time taken for clot formation is measured and compared to a calibration curve derived from known fibrinogen standards, providing a quantitative result.
Pathology Laboratory:Haematology
Requestable Seperately?No
Part of Profile:Coagulation Screen
Lower Reference Range Limit:1.5
Upper Reference Range Limit:4.5
Units:g/L
Minimum Sample Volume:to fill line
Expected Turnaround Time:<4 hours
Test Code:COAG
Sample Type:
Sodium Citrate Tube (Blue top)Maximum Add on Time:8 hours
Complex Reference Range:Age specific paediatric/neonatal reference range :-
Premature (24-29 weeks - Day 1) Cfib 0.62 - 4.21 g/L
Premature (30-36 weeks - Day 1) Cfib 1.50 - 3.07 g/L
Premature (30-36 weeks - Day 30) Cfib 1.50 - 4.14 g/L
Full term (37-40 weeks - Day 1) Cfib 1.67 - 3.99 g/L
Full term (37-40 weeks - Day 5) Cfib 1.62 - 4.62 g/L
Collection Conditions / Other Information:Full sample should be tested within 4 hours of specimen collection. Please contact the haematology laboratory for any Urgent requests
Paediatric sample tubes are available to order for children and difficult to bleed patients. These tubes require 1ml of blood to be taken.
Underfilled or overfilled samples will not be processed as the ratio of anticoagulant to blood in the tube will be incorrect.
Clotted and grossly haemolysed samples cannot be processed.
Haemolysis, Icterus and lipaemia may interfere with testing and so manual methods may be required to gain results.
Referred to Another Laboratory?No
Storage Requirements:Samples should be stored at room temperature and sent to the laboratory without delay.
EQA Scheme:UK NEQAS Coagulation
Site Sample Tested:New Cross Hospital - Haematology Laboratory
Walsall Manor Hospital - Haematology Laboratory
Midland Metropolitan University Hospital - Haematology Laboratory
Russells Hall Hospital - Haematology Laboratory
