Test Category: Specialist BiochemistryToxicology
Investigation Name:Clozapine
Alias or Abbreviation:CLZ
Intro:
Clozapine is used to treat schizophrenic illness and other neuropsychiatric diseases that do not respond to standard therapy. Clozapine can cause serious side effects and complications such as hypertension, neutropenia, and seizures. Norclozapine is a metabolite of clozapine and concentrations of these are measured to assess patient compliance, optimise dosage and minimise the risk of dose related toxicology.Pathology Laboratory:Toxicology Laboratory
Requestable Seperately?Yes
Units:µg/L
Minimum Sample Volume:2mL of EDTA blood or 1mL of plasma/serum.
Expected Turnaround Time:3 working days upon sample receipt
Test Code:CLZ
Sample Type:
A minimum of 2mL of EDTA whole blood or 1mL of plasma or serum is required.Complex Reference Range:Non-compliance, suboptimal dose <350µg/L
Maximum drug efficacy 350 - 600µg/L
Increased risk of side effects >600µg/L
Referred to Another Laboratory?No
Storage Requirements:Samples should be stored at 4°C and sent to the laboratory at ambient temperature using the normal postal system.
Posting Address / Requirements:Sandwell Health Campus
Specialist Chemistry,
Pathology Department,
Lyndon,
B71 4HJ
NPEX / PDF Reporting Available:NPEX and PDF reporting available.
EQA Scheme:The laboratory is enrolled on an EQA scheme for Therapeutic Drugs with LGC Standards PT schemes and samples are received monthly for this.
Further information: A trough sample is required pre-dose or a minimum of 12 hours post-dose.
Lead Contact Details:Lauren Starbrook, Consultant Clinical Scientist
Email: lauren.starbrook@nhs.net
Email Address For Chasing Results:rwh-tr.bcpsspecialistchemistryenquiries@nhs.net
Methodology:Analysed using HPLC-UV.
Site Sample Tested:City Health Campus
Cost:Please email: bcpspathology.info@nhs.net for further details
Contact Number:0121 507 4138
