Test Category: Immunology
Investigation Name:Gastric parietal cell antibody (GPC)
Alias or Abbreviation:GPC
Intro:
Indication: Autoimmune gastritis with or without pernicious anaemia Further information: Forms part of the Liver Auto-immune profile which includes tests for: • Mitochondrial antibody (AMA) • Smooth muscle antibody (SMA) • Liver- kidney microsomal antibody (LKM) • Gastric Parietal antibody (GPC) Gastric parietal cell antibodies (GPC) are directed against a parietal cell enzyme, the H+K+ATPase. The autoantibody is found at high frequency in association with autoimmune gastritis and a proportion of these patients will progress to develop pernicious anaemia. Gastric parietal cell antibodies are present in over 90% of patients with pernicious anaemia (Highly sensitive, but not specific). Note: Where GPC antibodies are observed within the Liver autoimmune profile, an Intrinsic factor antibody will be automatically added on.Requestable Seperately?No
Minimum Sample Volume:1mL
Expected Turnaround Time:Frequency of testing: Daily Target: 5 days
Test Code:LKS
Sample Type:
Serum Gel Tube (Gold top)Complex Reference Range:Positive/ Negative
Collection Conditions / Other Information:1st class post or Transport
Referred to Another Laboratory?No
Storage Requirements:Ambient temperature
NPEX / PDF Reporting Available:Yes
EQA Scheme:Yes
Further information:Available as part of the Liver Auto-immune profile only (LKS)
Lead Contact Details:rwh-tr.bcpsimmunologyclinicalqueries@nhs.net
Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net
Methodology:Indirect Immunofluorescence
UKAS Reference Number:Awaiting assessment
Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton
Minimum Request Interval (MRI):180 days (6 months) over 16y only
