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Test Category: Immunology

Investigation Name:Glomerular basement membrane IgG antibody

Alias or Abbreviation:GBM, Goodpasture’s

Intro:

Indication: Goodpasture’s syndrome Further information: Anti-glomerular basement membrane antibodies are found in Goodpasture's syndrome and levels correlate with disease activity and often predict clinical outcome. The autoantibody is directed against the NC1 domain of the α- chain of type IV collagen. Approximately 25% of patients presenting with anti GBM antibodies also present with anti-neutrophil cytoplasmic antibodies, so parallel testing is recommended. For Urgent testing please contact the laboratory directly.

Requestable Seperately?Yes

Minimum Sample Volume:0.25mL

Expected Turnaround Time:Frequency of testing: Daily Target: 3 days

Test Code:GBM

Sample Type:

Serum Gel Tube (Gold top)/ Plasma

Complex Reference Range:<7 U/mL = Negative

Collection Conditions / Other Information:1st class post or Transport

Referred to Another Laboratory?No

Storage Requirements:Ambient temperature

NPEX / PDF Reporting Available:Yes

EQA Scheme:Yes

Lead Contact Details:rwh-tr.bcpsimmunologyclinicalqueries@nhs.net

Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net

Methodology:Fluoroenzymeimmunoassay

UKAS Reference Number:9580 (recommended)

Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton