Test Category: Immunology
Investigation Name:Histone Antibody
Alias or Abbreviation:Histone
Accreditation:UKAS ISO15189:2022 Accredited test: On scope
Intro:
Indication:Systemic lupus erythematosus (SLE), drug induced SLE (DIL).
Further information:
Anti-histone antibodies are found in patients with SLE and patients with DIL. In SLE, anti-histone antibodies do not provide any better diagnostic information than DNA and anti-nuclear antibodies but in drug induced lupus, a typical antibody profile consists of antinuclear antibodies, anti-histone antibodies but rarely dsDNA antibodies and extractable nuclear antibodies.
Drugs implicated in DIL include hydralazine, procainamide and isoniazid. Histone antibodies can be positive in active lupus nephritis. Anti-histone antibodies have also been reported in selected cases of rheumatoid arthritis. Anti-histone antibody levels are reportedly higher in neuropsychiatric lupus.
Pathology Laboratory:Immunology Laboratory
Requestable Seperately?Yes
Minimum Sample Volume:2mL
Expected Turnaround Time:3 weeks
Test Code:HIST
Sample Type:
Serum Gel Tube (Gold top)Complex Reference Range:Normal = <40 U/mL
Reference Laboratory Details:Immunology and Protein Reference unit, Sheffield
Referred to Another Laboratory?Yes
Storage Requirements:Ambient temperature
Posting Address / Requirements:1st class post/ Trust transport
Lead Contact Details:Clinical queries email: rwh-tr.bcpsimmunologyclinicalqueries@nhs.net
Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net
Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton
Cost:Please email: bcpspathology.info@nhs.net for further details
Contact Number:01902 695 279 or Ext 85279
