Test Category: Specialist BiochemistryToxicology
Investigation Name:Lamotrigine
Alias or Abbreviation:LAMO/LAMOT
Accreditation:UKAS Accredited ISO15189:2022, on scope
Intro:
Lamotrigine is used to maintain bipolar 1 disorder and epilepsy. Adverse reactions of toxicity to this medication can cause Stevens-Johnson syndrome and toxic epidermal necrosis (TEN), as well as hallucinations, rash, nausea and hyponatraemia. Lamotrigine is measured to monitor compliance and to identify where adjustments in dosage are required.Pathology Laboratory:Toxicology
Requestable Seperately?Yes
Units:mg/L
Minimum Sample Volume:2mL of EDTA whole blood or 1mL of plasma or serum.
Expected Turnaround Time:2-3 working days post sample receipt.
Test Code:LAMO
Sample Type:
2mL of EDTA whole blood or 1mL of plasma or serum is required.Complex Reference Range:Therapeutic range (epilepsy): 1-4 mg/L
Maximum drug efficacy (bipolar disorder): 3-14 mg/L
Referred to Another Laboratory?No
Storage Requirements:Samples should be stored at 4oC and send at ambient temperature using the normal postal systems.
Posting Address / Requirements:Sandwell Health Campus,
Pathology Department,
Specialist Chemistry,
Lyndon,
B71 4HJ
NPEX / PDF Reporting Available:NPEX and PDF reporting available.
EQA Scheme:The laboratory is enrolled on an EQA scheme for Therapeutic Drugs with LGC Standards PT schemes and samples are received monthly.
Further information:A trough specimen is required pre-dose or a maximum of 6 hours post dose. Contact the laboratory on : Tel: 0121 507 4138
Lead Contact Details:Lauren Starbrook, Consultant Clinical Scientist,
Email: lauren.starbrook@nhs.net
Email Address For Chasing Results:rwh-tr.bcpsspecialistchemistryenquiries@nhs.net
Methodology: HPLC-UV
Site Sample Tested:City Health Campus
Cost:Please email: bcpspathology.info@nhs.net for further details
Contact Number:Tel: 0121 507 5162
