Test Category: Specialist BiochemistryToxicology
Investigation Name:Lamotrigine
Alias or Abbreviation:LAMO/LAMOT
Accreditation:UKAS Accredited ISO15189:2022, on scope
Intro:
Lamotrigine is primarily prescribed for the treatment of epilepsy and bipolar disorder. The risk of lamotrigine toxicity is low but toxicity can trigger severe skin reactions including Stevens Johnson Syndrome (SJS) or toxic epidermal necrolysis (TEN), which can be fatal.Measurement of serum lamotrigine is useful for monitoring adherence, ensuring therapeutic efficacy and prevention of toxicity. In addition changes in pharmacokinetics during pregnancy can affect drug concentrations.
Pathology Laboratory:Toxicology Laboratory
Requestable Seperately?Yes
Units:mg/L
Minimum Sample Volume:2mL of EDTA whole blood or 1mL of plasma or serum.
Expected Turnaround Time:7 working days post sample receipt.
Test Code:LAMO
Sample Type:
EDTA plasma or serum. SST gel tubes are permitted.Complex Reference Range:Therapeutic range (epilepsy): 1-4 mg/L
Maximum drug efficacy (bipolar disorder): 3-14 mg/L
Referred to Another Laboratory?No
Storage Requirements:Samples should be separated from cells and stored at 4 °C but can be sent at ambient temperature using routine postal systems.
Posting Address / Requirements:Sandwell Health Campus,
Pathology Department,
Specialist Chemistry,
Lyndon,
B71 4HJ
NPEX / PDF Reporting Available:NPEX and PDF reporting available.
EQA Scheme:The laboratory is enrolled on an EQA scheme for Therapeutic Drugs with LGC Standards PT schemes and samples are received monthly.
Further information:A trough specimen is required pre-dose or a maximum of 6 hours post dose.
Lead Contact Details:Hayley Sharrod-Cole, Consultant Clinical Scientist,
Email: hayley.sharrod-cole@nhs.net
Email Address For Chasing Results:rwh-tr.bcpsspecialistchemistryenquiries@nhs.net
Methodology: HPLC-UV
Site Sample Tested:City Health Campus
Cost:Please email: bcpspathology.info@nhs.net for further details
Contact Number:Tel: 0121 507 5162
