Test Category: Specialist BiochemistryToxicology
Investigation Name:Olanzapine
Alias or Abbreviation:OLZ/ OLANZ
Accreditation:UKAS Accredited ISO 15189:2022, on scope
Intro:
Olanzapine is an atypical antipsychotic commonly used in the treatment of schizophrenia and bipolar disorder. While routine therapeutic drug monitoring is not standard practice for all patients on olanzapine, measurement may be indicated in suspected non-compliance or when patients exhibit suboptimal therapeutic response or unexpected adverse effects, such as excessive sedation, metabolic disturbances, or extrapyramidal symptoms, which may suggest either underdosing or toxicity.Pathology Laboratory:Toxicology Laboratory
Requestable Seperately?Yes
Units: µg/L
Minimum Sample Volume:500uL whole blood or 250 uL plasma
Expected Turnaround Time:7 working days from sample receipt.
Test Code:OLZ
Sample Type:
EDTA, LiHep and serum (gel free preferred)Complex Reference Range:Maximum drug efficacy 20-40 µg/L
Risk of severe toxicity >100 µg/L
Trough specimen taken pre dose or minimum 12 hrs post dose.
Referred to Another Laboratory?No
Storage Requirements:Not stable in whole blood. Plasma is stable for 3 days at ambient temperatures and 2 weeks at 2–8 °C.
Posting Address / Requirements:Sandwell Health Campus
Specialist Chemistry
Pathology Department
Lyndon
B71 4HJ
NPEX / PDF Reporting Available:NPEX and PDF reporting available.
EQA Scheme:LGC Toxicology TDM Scheme.
Further information:Samples should be collected immediately before the next dose, i.e. pre-dose (trough), or a minimum 12 hours post-dose.
Therapeutic ranges only apply to pre-dose (trough) samples.
Lead Contact Details:Hayley Sharrod-Cole, Consultant Clinical Scientist
Email: hayley.sharrod-cole@nhs.net
Email Address For Chasing Results:rwh-tr.bcpsspecialistchemistryenquiries@nhs.net
Methodology:UPLC -MS/MS
Site Sample Tested:City Health Campus
Cost:Please email: bcpspathology.info@nhs.net for further details
Contact Number:0121 507 4138
