Pneumococcal Serotype Specific Antibodies - Black Country Pathology Services

Investigation Name:Pneumococcal Serotype Specific Antibodies

Intro:

Indication: Immunodeficiency
Further information:
Functional antibodies should only be requested if there is a clinical suspicion of antibody deficiency (primary or secondary). The recommended first line Immunology tests are:-
• Immunoglobulin levels (IgG, IgA and IgM)
• Electrophoresis
The second line testing, which includes functional antibodies, should only be requested if:-
• There is a strong clinical history of recurrent or persistent infection
• At least 2 Immunoglobulin isotypes are lower than reference limits
• To assess immune response to vaccines (pre- and post-vaccine)
This assay is used to monitor IgG responses to the Prevenar and Pneumovax vaccines, in patients with suspected immunodeficiency. Samples should ideally be tested pre- and post- vaccination. The serotypes available are 1, 3, 4, 5, 6b, 7F, 9V, 14, 18c, 19A, 19F and 23F which are in both the Pneumovax and Prevenar vaccines.

Pathology Laboratory:Immunology Laboratory

Requestable Seperately?Yes

Minimum Sample Volume:1mL

Expected Turnaround Time:28 working days

Test Code:PNAB

Sample Type:

Serum Gel Tube (Gold top)

Complex Reference Range:See report

Collection Conditions / Other Information:Functional antibodies should only be requested if there is a clinical suspicion of antibody deficiency (primary or secondary).
The recommended first line Immunology tests are:-
• Immunoglobulin levels (IgG, IgA and IgM)
• Electrophoresis

Reference Laboratory Details:PRU, Sheffield

Referred to Another Laboratory?Yes

Storage Requirements:Ambient temperature

Posting Address / Requirements:1st class post/ Trust transport

Lead Contact Details:Clinical queries email: rwh-tr.bcpsimmunologyclinicalqueries@nhs.net

Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net

Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton

Contact Number:01902 695 279 or Ext 85279