Investigation Name:Procollagen III peptide

Alias or Abbreviation:P3NP or PIIINP

Pathology Laboratory:Chemistry Referred Ext 85290

Requestable Seperately?No

E-Requesting Tab:Other

Upper Reference Range Limit:8.1

Units:ug/L

Minimum Sample Volume:1mL

Expected Turnaround Time:7-10 working days

Test Code:P3NP

Sample Type:

Maximum Add on Time:N/A

Complex Reference Range:≤8.1 Results within reference range. Monitor P3NP 2-3 monthly during methotrexate treatment. 8.2 – 14 P3NP >8.1ug/L on 3 separate occasions in a 12 month period requires further investigation and assessment. (See BSR/BHPR guidelines 14.1 - 17.9 P3NP >14.0 ug/L on 2 separate occasions in a 12 month period requires further investigation and assessment. (See BSR/BHPR guidelines) >17.9 The withdrawal of methotrexate should be considered when P3NP is >17.9 ug/L on 3 separate occasions in a 12 month period (See BSR/BHPR guidelines)P3NP 6 P3NP measured by Siemens immunoassay. New therapeutic thresholds based on radioimmunoassy action limits - The decision whether to perform liver biopsy, withdraw or continue treatment despite raised P3NP must also take into account other factors such as patient age, disease severity, and the ease with which alternative therapies may be used in place of methotrexate (see BSR/BHPR guidelines). P3NP7 - Increased extra-hepatic collagen turnover (e.g. active erosive arthritis or bone fractures) may cause raised P3NP

Collection Conditions / Other Information:Needs to be stored at -20c within 3 hours.

Reference Laboratory Details:Clinical Chemistry Department, Russells Hall Hospital, Pensnett Road, DUDLEY, DY1 2HQ. Telephone: 01384 456 111 Ext 2086

Referred to Another Laboratory?Yes

Reference Lab Code:RHH