Test Category: Specialist BiochemistryToxicology
Investigation Name:Quetiapine
Alias or Abbreviation:QUET/QUE
Accreditation:UKAS Accredited ISO15189:2022, on scope
Intro:
Quetiapine is an atypical antipsychotic used in the management of schizophrenia, bipolar disorder, and major depressive disorder. While routine therapeutic drug monitoring is not standard practice, measurement may can be beneficial in suspected non-compliance, or in patients with an inadequate therapeutic response or unexpected side effects, such as excessive sedation, hypotension, or metabolic disturbances, which could suggest subtherapeutic or toxic drug levels.Pathology Laboratory:Toxicology Laboratory
Requestable Seperately?Yes
Units:µg/L
Minimum Sample Volume:500uL whole blood or 250 uL plasma
Expected Turnaround Time:7 working days
Test Code:QUE
Sample Type:
EDTA, LiHep and serum (gel free preferred)Complex Reference Range:Maximum drug efficacy 50-200 µg/L
Trough specimen taken pre dose or minimum 12 hrs post dose
Referred to Another Laboratory?No
Storage Requirements:At ambient temperatures stable for 2 days in whole blood.
Plasma/serum stable for 3 days at ambient temperatures and 3 weeks at 2–8 °C.
Recommend separating plasma/serum if sending via routine post.
Posting Address / Requirements:Sandwell Health Campus
Specialist Chemistry
Pathology Department
Lyndon
B71 4HJ
NPEX / PDF Reporting Available:NPEX and PDF reporting available.
EQA Scheme:LCG Toxicology TDM Scheme.
Further information:Samples should be collected immediately before the next dose, i.e. pre-dose (trough), or a minimum 12 hours post-dose.
Therapeutic ranges only apply to pre-dose (trough) samples.
Lead Contact Details:Hayley Sharrod-Cole, Consultant Clinical Scientist
Email: hayley.sharrod-cole@nhs.net
Email Address For Chasing Results:rwh-tr.bcpsspecialistchemistryenquiries@nhs.net
Methodology:UPLC-MS/MS
Site Sample Tested:City Health Campus
Cost:Please email: bcpspathology.info@nhs.net for further details
Contact Number:0121 507 4138
