Test Category: Specialist Biochemistry
Investigation Name:Red Cell Cholinesterase
Accreditation:UKAS ISO15189:2022 accredited test: On scope
Intro:
Poisoning due to organophosphorus and carbamate insecticides is uncommon in the UK though fatalities still occur. Organophosphorus and carbamate insecticides covalently inhibit neural, erythrocyte and plasma cholinesterase to varying extents and with different time courses.Acetylcholinesterase is present in human erythrocytes as well as in the target synapses and the activity of acetylcholinesterase in red cells is assumed to mirror that in the target organs (liver, pancreas, heart, white matter of the brain).
Pathology Laboratory:Manuals Laboratory
Requestable Seperately?Yes
Minimum Sample Volume:2mls plasma EDTA preservative.
Expected Turnaround Time:1 working day
Sample Type:
EDTA whole blood is required.Cholinesterase is stable in whole blood without loss of activity for 7 days at 2-8 0C and for <24hrs at 15-300C.
Samples should be brought to room temperature and mixed before analysis.
Red cell only samples, i.e., samples which have been undergone red cell washing and separation from plasma, are stable at -20°C for one month, but consideration of a possible decrease in activity of 16-32% is essential during result interpretation.
Complex Reference Range:≥2777 U/L
Collection Conditions / Other Information:Classed as an urgent test. Please contact the laboratory prior to sending sample.
Same day transport – ideally within 6 hours of collection.
Notification on the expectation time of samples is ideally required.
Send without ice / cool pack unless same day transport is not possible, in such scenarios it is advised to store at +2-8 C° and transported at +2-8 °C.
If sample cannot be sent on the same day, please store at +2-8 °C and inform laboratory when sample is being sent.
Referred to Another Laboratory?No
Reference Lab Code:CHOR
Storage Requirements:Store samples at +2-8 C° prior to urgently sending via taxi/courier.
Posting Address / Requirements:Sandwell Health Campus,
Pathology Department,
Specialist Chemistry,
Lyndon
B71 4HJ
NPEX / PDF Reporting Available:Yes
EQA Scheme:Exchange scheme with Defence Science & Technology Laboratory, Porton Down.
Lead Contact Details:Consultant Clinical Scientist, Hayley Sharrod-Cole Email: hayley.sharrod-cole@nhs.net
Email Address For Chasing Results:rwh-tr.bcpsspecialistchemistryenquiries@nhs.net
Site Sample Tested:Sandwell Health Campus
Cost:Please email: bcpspathology.info@nhs.net for further details
Contact Number:01215075162
