Test Category: Immunology
Investigation Name:dsDNA (Quantification)
Alias or Abbreviation:DNA
Intro:
Indication: Diagnosis and monitoring of SLE, autoimmune liver disease. Further information: dsDNA antibodies are highly specific markers of SLE and autoimmune (lupoid) hepatitis. Raised levels are found in 50-70% of patients with SLE and tend to correlate with disease activity. Raised levels may also be seen in a small minority of patients with chronic active hepatitis. The presence of anti-DNA is one of the American Rheumatism Association criteria for SLE and the antibody is rarely found in high levels in patients with other rheumatic diseases. However, anti-dsDNA antibodies are frequently found in patients with overlap symptoms between SLE and other autoimmune diseases. NOTE: dsDNA by Crithidia will be reflexed on new positive dsDNA.Requestable Seperately?Yes
Minimum Sample Volume:1mL
Test Code:DNA
Sample Type:
Serum Gel Tube (Gold top)/ PlasmaComplex Reference Range:<10 IU/mL = Negative
Collection Conditions / Other Information:1st class post or Transport
Referred to Another Laboratory?No
Storage Requirements:Ambient temperature
NPEX / PDF Reporting Available:Yes
EQA Scheme:Yes
Lead Contact Details:rwh-tr.bcpsimmunologyclinicalqueries@nhs.net
Email Address For Chasing Results:rwh-tr.ImmunologyLab@nhs.net
Methodology:Fluoroenzymeimmunoassay
UKAS Reference Number:9580 (recommended)
Site Sample Tested:Immunology, New Cross Hospital, Wolverhampton
Minimum Request Interval (MRI):7 days (1 week) over 16y only
